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PIK3R2
Basic information
- Official gene symbol
-
phosphoinositide-3-kinase regulatory subunit 2
- Conventional gene symbol
-
MPPH1, P85B, p85-BETA
- Classification
-
Oncogene / Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
-
Tumor growth and progression
- Signaling pathway
-
PI3K/Akt/mTOR
- Chromosomal location
-
19p13.11 (chr19:18266690..18280104)
- Protein length
-
728
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr19:18273086 | C | T | 8 / 16 | p.Q326* | c.976C>T | Tier2 | 1 / 63 | |
| chr19:18273784 | G | A | 10 / 16 | p.G373R | c.1117G>A | COSV55846573 | Tier2 | 4 / 63 |
| chr19:18274100 | G | T | 11 / 16 | p.E440* | c.1318G>T | Tier2 | 1 / 63 | |
| chr19:18279698 | C | A | 15 / 16 | p.C657* | c.1971C>A | Tier2 | 1 / 63 | |
| chr19:18280053 | GGCGCACCCAGT | G | 16 / 16 | p.H714fs | c.2141_2151delACCCAGTGCGC | Tier2 | 1 / 63 |