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POLD1

Basic information

Official gene symbol
DNA polymerase delta 1, catalytic subunit
Conventional gene symbol
CDC2, CRCS10, MDPL, POLD
Classification
Tumor suppressor gene
Official gene ID
5424(Refseq)
5424 (KEGG)
Transcript ID
NM_001256849
Functional classification
Genome maintenance
Signaling pathway
DNA damage control
Chromosomal location
19q13.33 (chr19:50902109..50921204)
Protein length
1,107

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr19:50905285 C T 5 / 27 p.Q165* c.493C>T   Tier2 1 / 103
chr19:50905328 GGA G 5 / 27 p.R180fs c.538_539delAG   Tier2 1 / 103
chr19:50905329 GA G 5 / 27 p.R180fs c.538delA   Tier2 1 / 103
chr19:50906474 C T 9 / 27 p.Q379* c.1135C>T   Tier2 1 / 103
chr19:50909713 G A 12 / 27 p.S478N c.1433G>A COSV70955559 Tier2 1 / 103
chr19:50912919 C G 17 / 27 p.S717* c.2150C>G   Tier2 1 / 103
chr19:50920349 AAGG A 25 / 27 p.E1040fs c.3119_3120+1delAGG   Tier2 1 / 103
chr19:50920470 CTG C 26 / 27 p.W1055fs c.3163_3164delTG   Tier2 1 / 103