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PPP2R1A

Basic information

Official gene symbol
protein phosphatase 2 scaffold subunit Aalpha
Conventional gene symbol
MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A
Classification
Oncogene / Tumor suppressor gene
Official gene ID
5518(Refseq)
5518 (KEGG)
Transcript ID
NM_014225
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
19q13.41 (chr19:52693350..52729234)
Protein length
589

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr19:52715971 C G 5 / 15 p.P179R c.536C>G COSV59042232 Tier2 3 / 89
chr19:52715979 C T 5 / 15 p.R182W c.544C>T COSV59042121 Tier2 2 / 89
chr19:52715982 C T 5 / 15 p.R183W c.547C>T COSV59042187 Tier2 10 / 89
chr19:52715983 G A 5 / 15 p.R183Q c.548G>A COSV59042295 Tier2 6 / 89
chr19:52716323 C A 6 / 15 p.S256Y c.767C>A COSV59042723 Tier2 1 / 89
chr19:52716323 C T 6 / 15 p.S256F c.767C>T COSV59042523 Tier2 2 / 89
chr19:52719275 C G 8 / 15 p.S314* c.941C>G   Tier2 1 / 89