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PRKN

Basic information

Official gene symbol
parkin RBR E3 ubiquitin protein ligase
Conventional gene symbol
AR-JP, LPRS2, PARK2, PDJ
Classification
Tumor suppressor gene
Official gene ID
5071(Refseq)
5071 (KEGG)
Transcript ID
NM_004562
Functional classification
Protein homeostasis
Signaling pathway
Protein homeostasis
Chromosomal location
6q26 (chr6:161771131..163148700, complement)
Protein length
465

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr6:162683677 C A 3 / 12 p.E98* c.292G>T COSV100629251 Tier2 1 / 80
chr6:162683734 C A 3 / 12 p.E79* c.235G>T COSV58264485 Tier2 1 / 80
chr6:162683748 C T 3 / 12 p.W74* c.221G>A COSV58227379 Tier2 1 / 80
chr6:162394349 GT G 6 / 12 p.T240fs c.718delA   Tier2 1 / 80
chr6:161969993 G A 9 / 12 p.Q326* c.976C>T   Tier2 1 / 80
chr6:161970011 C CA 9 / 12 p.A320fs c.957dupT   Tier2 1 / 80