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PTPN11
Basic information
- Official gene symbol
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protein tyrosine phosphatase non-receptor type 11
- Conventional gene symbol
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BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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MAPK
- Chromosomal location
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12q24.13 (chr12:112856916..112942568)
- Protein length
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593
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr12:112888210 | G | A | 3 / 16 | p.E76K | c.226G>A | COSV61004889 | Tier1 | 1 / 38 |
| chr12:112926248 | G | A | 12 / 16 | p.A461T | c.1381G>A | COSV61005148 | Tier2 | 3 / 38 |
| chr12:112926888 | G | T | 13 / 16 | p.G503V | c.1508G>T | COSV61005158 | Tier2 | 3 / 38 |