Side Menu

PTPRT

Basic information

Official gene symbol
protein tyrosine phosphatase receptor type T
Conventional gene symbol
RPTPrho
Classification
Tumor suppressor gene
Official gene ID
11122(Refseq)
11122 (KEGG)
Transcript ID
NM_007050
Functional classification
Tumor growth and progression
Signaling pathway
RTK
Chromosomal location
20q12-q13.11 (chr20:40709519..41818373, complement)
Protein length
1,441

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr20:41400170 G A 5 / 31 p.R197* c.589C>T COSV61982755 Tier2 2 / 259
chr20:41306569 G A 7 / 31 p.R364* c.1090C>T COSV61965733 Tier2 1 / 259
chr20:41100975 G A 8 / 31 p.R461* c.1381C>T COSV61958074 Tier2 1 / 259
chr20:41100999 G A 8 / 31 p.R453C c.1357C>T COSV61960613 Tier2 1 / 259
chr20:40979319 G A 11 / 31 p.T605M c.1814C>T COSV62017284 Tier2 1 / 259
chr20:40944567 G T 12 / 31 p.C645* c.1935C>A   Tier2 1 / 259
chr20:40864874 A T 15 / 31 p.Y779* c.2337T>A   Tier2 1 / 259
chr20:40827919 C A 16 / 31 p.E818* c.2452G>T   Tier2 1 / 259
chr20:40748602 G A 20 / 31 p.R953* c.2857C>T COSV99049486 Tier2 1 / 259
chr20:40747110 C T 21 / 31 p.W972* c.2915G>A COSV61969190 Tier2 1 / 259
chr20:40743943 G A 22 / 31 p.R999* c.2995C>T COSV62002420 Tier2 2 / 259
chr20:40714412 C A 28 / 31 p.E1310* c.3928G>T   Tier2 1 / 259
chr20:40714455 G T 28 / 31 p.C1295* c.3885C>A COSV61990149 Tier2 1 / 259
chr20:40713383 G A 29 / 31 p.R1359* c.4075C>T COSV62003161 Tier2 1 / 259