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RAF1
Basic information
- Official gene symbol
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Raf-1 proto-oncogene, serine/threonine kinase
- Conventional gene symbol
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CMD1NN, CRAF, NS5, Raf-1, c-Raf
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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MAPK
- Chromosomal location
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3p25.2 (chr3:12626013..12660220, complement)
- Protein length
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648
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr3:12645694 | A | G | 7 / 17 | p.S259P | c.775T>C | COSV52577994 | Tier2 | 1 / 55 |
| chr3:12645694 | A | C | 7 / 17 | p.S259A | c.775T>G | COSV52586258 | Tier1 | 1 / 55 |
| chr3:12645699 | G | A | 7 / 17 | p.S257L | c.770C>T | COSV52574378 | Tier1 | 11 / 55 |
| chr3:12633229 | T | A | 11 / 17 | p.R391W | c.1171A>T | COSV52577112(SNP) | Tier2 | 1 / 55 |