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RBM10

Basic information

Official gene symbol
RNA binding motif protein 10
Conventional gene symbol
DXS8237E, GPATC9, GPATCH9, S1-1, TARPS, ZRANB5
Classification
Tumor suppressor gene
Official gene ID
8241(Refseq)
8241 (KEGG)
Transcript ID
NM_005676
Functional classification
Transcriptional regulation
Signaling pathway
RNA metabolism
Chromosomal location
Xp11.3 (chrX:47006881..47045998)
Protein length
930

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chrX:47028763 C T 3 / 24 p.Q23* c.67C>T   Tier2 1 / 127
chrX:47028790 C CGA 3 / 24 p.D33fs c.97_98dupGA   Tier2 1 / 127
chrX:47028828 T G 3 / 24 p.Y44* c.132T>G COSV61309029 Tier2 1 / 127
chrX:47035912 TC T 7 / 24 p.L198fs c.592delC   Tier2 1 / 127
chrX:47035983 A T 7 / 24 p.K221* c.661A>T   Tier2 1 / 127
chrX:47038526 C T 8 / 24 p.R230* c.688C>T COSV61309636 Tier2 2 / 127
chrX:47038726 C T 9 / 24 p.Q245* c.733C>T COSV61313432 Tier2 1 / 127
chrX:47038751 TG T 9 / 24 p.D254fs c.760delG   Tier2 1 / 127
chrX:47038846 C T 9 / 24 p.Q285* c.853C>T COSV61312003 Tier2 1 / 127
chrX:47039406 CG C 10 / 24 p.G344fs c.1031delG   Tier2 1 / 127
chrX:47039613 GGCAGCCCA G 11 / 24 p.Q358fs c.1068_1075delAGCCCAGC   Tier2 1 / 127
chrX:47040939 CTG C 14 / 24 p.S492fs c.1473_1474delGT   Tier2 1 / 127
chrX:47041199 ACC A 15 / 24 p.H544fs c.1629_1630delCC   Tier2 1 / 127
chrX:47041211 TCTGCTCTCCCACCGGCTACCAGCCCCACTGCCCAGGAATC T 15 / 24 p.A548fs c.1642_1681delGCTCTCCCACCGGCTACCAGCCCCACTGCCCAGGAATCCT   Tier2 1 / 127
chrX:47041384 GA G 16 / 24 p.T577fs c.1729delA   Tier2 1 / 127
chrX:47041599 G A 17 / 24 p.W608* c.1824G>A   Tier2 1 / 127
chrX:47044550 G T 18 / 24 p.E683* c.2047G>T COSV61308334 Tier2 1 / 127
chrX:47044595 G T 18 / 24 p.E698* c.2092G>T COSV61307701 Tier2 1 / 127
chrX:47044713 G T 19 / 24 p.E705* c.2113G>T COSV61307871 Tier2 1 / 127
chrX:47044753 GT G 19 / 24 p.S718fs c.2154delT   Tier2 1 / 127
chrX:47044892 G T 20 / 24 p.E740* c.2218G>T COSV61309228 Tier2 1 / 127
chrX:47044946 A T 20 / 24 p.K758* c.2272A>T   Tier2 1 / 127
chrX:47045124 G T 21 / 24 p.E789* c.2365G>T COSV61309684 Tier2 1 / 127
chrX:47045149 C G 21 / 24 p.S797* c.2390C>G   Tier2 1 / 127
chrX:47045464 C T 22 / 24 p.Q811* c.2431C>T   Tier2 1 / 127
chrX:47045518 G T 22 / 24 p.E829* c.2485G>T COSV61311914 Tier2 1 / 127
chrX:47045678 GGACGGGCTGGGCA G 23 / 24 p.D854fs c.2561_2573delACGGGCTGGGCAG   Tier2 1 / 127