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RET
Basic information
- Official gene symbol
-
ret proto-oncogene
- Conventional gene symbol
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CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, RET-ELE1
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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RTK
- Chromosomal location
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10q11.21 (chr10:43572707..43623717)
- Protein length
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1,114
Chromosome ideogram
Pathway map
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr10:43607555 | G | A | 8 / 20 | p.E511K | c.1531G>A | COSV60701393 | Tier2 | 2 / 138 |
| chr10:43615083 | C | T | 14 / 20 | p.R833C | c.2497C>T | COSV60700472 | Tier2 | 1 / 138 |