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RHOA

Basic information

Official gene symbol
ras homolog family member A
Conventional gene symbol
ARH12, ARHA, EDFAOB, RHO12, RHOH12
Classification
Oncogene / Tumor suppressor gene
Official gene ID
387(Refseq)
387 (KEGG)
Transcript ID
NM_001313941
Functional classification
Tumor growth and progression
Signaling pathway
MAPK
Chromosomal location
3p21.31 (chr3:49397642..49413022, complement)
Protein length
193

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr3:49412898 T C 3 / 6 p.Y42C c.125A>G COSV69041523 Tier1 2 / 40
chr3:49412905 C G 3 / 6 p.E40Q c.118G>C COSV69041613 Tier2 1 / 40
chr3:49412905 C T 3 / 6 p.E40K c.118G>A COSV69042111 Tier2 1 / 40
chr3:49412922 T A 3 / 6 p.Y34F c.101A>T COSV69042084 Tier2 1 / 40
chr3:49412922 T C 3 / 6 p.Y34C c.101A>G COSV69041520 Tier2 1 / 40
chr3:49412973 C T 3 / 6 p.G17E c.50G>A COSV69041693 Tier2 3 / 40
chr3:49413009 C T 3 / 6 p.R5Q c.14G>A COSV69041526 Tier2 1 / 40
chr3:49413010 G A 3 / 6 p.R5W c.13C>T COSV69041759 Tier2 1 / 40
chr3:49405969 A C 4 / 6 p.L57V c.169T>G COSV69041945 Tier1 1 / 40