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RNF43

Basic information

Official gene symbol
ring finger protein 43
Conventional gene symbol
RNF124, SSPCS, URCC
Classification
Tumor suppressor gene
Official gene ID
54894(Refseq)
54894 (KEGG)
Transcript ID
NM_017763
Functional classification
Differentiation
Signaling pathway
WNT
Chromosomal location
17q22 (chr17:56432304..56492938, complement)
Protein length
783

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:56492693 TA T 2 / 10 p.L82fs c.245delT   Tier2 1 / 102
chr17:56492694 A C 2 / 10 p.L82* c.245T>G COSV60416856 Tier2 1 / 102
chr17:56448274 T TGCTA 3 / 10 p.K125fs c.369_372dupTAGC   Tier2 1 / 102
chr17:56448310 G A 3 / 10 p.R113* c.337C>T COSV68457279 Tier2 1 / 102
chr17:56440904 G A 4 / 10 p.R145* c.433C>T COSV68456834 Tier2 1 / 102
chr17:56440919 CAA C 4 / 10 p.F139fs c.416_417delTT   Tier2 1 / 102
chr17:56440943 G A 4 / 10 p.R132* c.394C>T COSV68457376 Tier2 7 / 102
chr17:56440676 TTTTGGTTC T 5 / 10 p.N179fs c.534_541delGAACCAAA   Tier2 1 / 102
chr17:56440761 G A 5 / 10 p.Q153* c.457C>T COSV68459258 Tier2 1 / 102
chr17:56439992 C T 6 / 10 p.W200* c.600G>A COSV68457592 Tier2 1 / 102
chr17:56439993 C T 6 / 10 p.W200* c.599G>A COSV68459246 Tier2 2 / 102
chr17:56438216 C T 7 / 10 p.W259* c.777G>A COSV68457166 Tier2 1 / 102
chr17:56438269 G A 7 / 10 p.Q242* c.724C>T COSV68459333 Tier2 1 / 102
chr17:56438280 C T 7 / 10 p.W238* c.713G>A COSV104435047 Tier2 1 / 102
chr17:56438293 G A 7 / 10 p.Q234* c.700C>T   Tier2 1 / 102
chr17:56438296 G A 7 / 10 p.Q233* c.697C>T COSV68459713 Tier2 1 / 102
chr17:56435536 TCCAAGGAACGAGG T 9 / 10 p.P530fs c.1588_1600delCCTCGTTCCTTGG   Tier2 1 / 102
chr17:56435933 G A 9 / 10 p.Q402* c.1204C>T   Tier2 1 / 102
chr17:56436128 G A 9 / 10 p.R337* c.1009C>T COSV68456791 Tier2 1 / 102
chr17:56436149 G A 9 / 10 p.R330* c.988C>T COSV68457287 Tier2 2 / 102