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SDHA

Basic information

Official gene symbol
succinate dehydrogenase complex flavoprotein subunit A
Conventional gene symbol
CMD1GG, FP, PGL5, SDHF
Classification
Tumor suppressor gene
Official gene ID
6389(Refseq)
6389 (KEGG)
Transcript ID
NM_004168
Functional classification
Metabolism
Signaling pathway
Metabolic pathway
Chromosomal location
5p15.33 (chr5:218471..256535)
Protein length
664

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr5:223621 ACCCGAGGTTTTCACTT A 2 / 15 p.R31fs c.90_105delCCGAGGTTTTCACTTC   Tier2 1 / 64
chr5:224547 C T 3 / 15 p.R75* c.223C>T COSV53774237 Tier2 1 / 64
chr5:228426 A T 6 / 15 p.K250* c.748A>T   Tier2 1 / 64
chr5:233681 C T 8 / 15 p.R329* c.985C>T COSV53769941 Tier2 1 / 64
chr5:236671 TG T 10 / 15 p.G464fs c.1391delG   Tier2 1 / 64
chr5:240574 C T 11 / 15 p.R512* c.1534C>T COSV53770500 Tier2 1 / 64