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SF3B1
Basic information
- Official gene symbol
-
splicing factor 3b subunit 1
- Conventional gene symbol
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Hsh155, PRP10, PRPF10, SAP155, SF3b155
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Transcriptional regulation
- Signaling pathway
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RNA metabolism
- Chromosomal location
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2q33.1 (chr2:198257027..198299723, complement)
- Protein length
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1,304
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr2:198267360 | T | G | 14 / 25 | p.K666T | c.1997A>C | COSV59207657 | Tier2 | 1 / 96 |
| chr2:198267483 | C | T | 14 / 25 | p.R625H | c.1874G>A | COSV59205431 | Tier2 | 1 / 96 |
| chr2:198267484 | G | A | 14 / 25 | p.R625C | c.1873C>T | COSV59205859 | Tier2 | 2 / 96 |
| chr2:198266834 | T | C | 15 / 25 | p.K700E | c.2098A>G | COSV59205318 | Tier2 | 11 / 96 |
| chr2:198266611 | C | T | 16 / 25 | p.G742D | c.2225G>A | COSV59205440 | Tier2 | 1 / 96 |
| chr2:198265007 | C | T | 19 / 25 | p.R957Q | c.2870G>A | COSV59206258 | Tier2 | 1 / 96 |