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SLX4
Basic information
- Official gene symbol
-
SLX4 structure-specific endonuclease subunit
- Conventional gene symbol
-
BTBD12, FANCP, MUS312
- Classification
-
Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
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Genome maintenance
- Signaling pathway
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DNA damage control
- Chromosomal location
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16p13.3 (chr16:3632343..3658965, complement)
- Protein length
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1,834
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr16:3639245 | CGGCTGTCG | C | 12 / 15 | p.D1463fs | c.4386_4393delCGACAGCC | Tier2 | 1 / 124 | |
| chr16:3639900 | C | A | 12 / 15 | p.E1247* | c.3739G>T | Tier2 | 1 / 124 | |
| chr16:3640335 | C | A | 12 / 15 | p.E1102* | c.3304G>T | Tier2 | 1 / 124 | |
| chr16:3633102 | G | A | 14 / 15 | p.Q1717* | c.5149C>T | Tier2 | 1 / 124 | |
| chr16:3633150 | C | A | 14 / 15 | p.E1701* | c.5101G>T | Tier2 | 1 / 124 | |
| chr16:3633255 | G | A | 14 / 15 | p.R1666* | c.4996C>T | Tier2 | 1 / 124 |