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SOS1
Basic information
- Official gene symbol
-
SOS Ras/Rac guanine nucleotide exchange factor 1
- Conventional gene symbol
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GF1, GGF1, GINGF, NS4, SOS-1
- Classification
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Oncogene
- Official gene ID
- Transcript ID
- Functional classification
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Tumor growth and progression
- Signaling pathway
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MAPK
- Chromosomal location
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2p22.1 (chr2:39212965..39347563, complement)
- Protein length
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1,333
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr2:39281778 | T | A | 5 / 23 | p.N233Y | c.697A>T | COSV67673722 | Tier2 | 2 / 66 |
| chr2:39278343 | A | C | 6 / 23 | p.M269R | c.806T>G | COSV67674247 | Tier2 | 1 / 66 |
| chr2:39250269 | C | T | 10 / 23 | p.G434R | c.1300G>A | COSV67677492 | Tier2 | 1 / 66 |
| chr2:39234309 | C | T | 16 / 23 | p.E846K | c.2536G>A | COSV67673763 | Tier2 | 2 / 66 |