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SPEN

Basic information

Official gene symbol
spen family transcriptional repressor
Conventional gene symbol
HIAA0929, MINT, RBM15C, SHARP
Classification
Tumor suppressor gene
Official gene ID
23013(Refseq)
23013 (KEGG)
Transcript ID
NM_015001
Functional classification
Transcriptional regulation
Signaling pathway
Transcriptional regulation
Chromosomal location
1p36.21-p36.13 (chr1:16174563..16265922)
Protein length
3,664

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr1:16203058 CAG C 3 / 15 p.R257fs c.770_771delGA   Tier2 1 / 182
chr1:16255235 C T 11 / 15 p.Q834* c.2500C>T   Tier2 1 / 182
chr1:16255248 CGGACCAAG C 11 / 15 p.D839fs c.2514_2521delGGACCAAG   Tier2 1 / 182
chr1:16255424 G T 11 / 15 p.E897* c.2689G>T   Tier2 1 / 182
chr1:16255547 AAAGT A 11 / 15 p.K938fs c.2814_2817delAGTA   Tier2 1 / 182
chr1:16255757 G T 11 / 15 p.E1008* c.3022G>T   Tier2 1 / 182
chr1:16255862 G T 11 / 15 p.E1043* c.3127G>T COSV65361516 Tier2 1 / 182
chr1:16256039 C T 11 / 15 p.Q1102* c.3304C>T   Tier2 1 / 182
chr1:16256528 C T 11 / 15 p.R1265* c.3793C>T COSV65357409 Tier2 1 / 182
chr1:16260956 GT G 11 / 15 p.V2741fs c.8222delT   Tier2 1 / 182
chr1:16265824 G T 15 / 15 p.E3633* c.10897G>T   Tier2 1 / 182