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SPOP
Basic information
- Official gene symbol
-
speckle type BTB/POZ protein
- Conventional gene symbol
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BTBD32, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2
- Classification
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Oncogene / Tumor suppressor gene
- Official gene ID
- Transcript ID
- Functional classification
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Protein homeostasis
- Signaling pathway
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Protein homeostasis
- Chromosomal location
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17q21.33 (chr17:47677740..47700172, complement)
- Protein length
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374
Chromosome ideogram
Frequency of somatic alterationsTumor type
Base substitutions, insertions, and deletions
Copy number alterations
Distribution of tumor mutation burdenTMB
List of driver somatic mutations
| Genomic Coordinates (GRCh37/hg19) | Reference | Variant | Exon | Amino Acid change | Coding DNA change | COSMIC (v92) | Classification | No. of Samples |
|---|---|---|---|---|---|---|---|---|
| chr17:47699360 | C | T | 5 / 12 | p.E50K | c.148G>A | COSV61652768 | Tier2 | 1 / 38 |
| chr17:47696599 | T | C | 6 / 12 | p.M117V | c.349A>G | COSV61652945 | Tier2 | 2 / 38 |
| chr17:47679360 | C | A | 11 / 12 | p.E283* | c.847G>T | Tier2 | 1 / 38 |