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STK11

Basic information

Official gene symbol
serine/threonine kinase 11
Conventional gene symbol
LKB1, PJS, hLKB1
Classification
Tumor suppressor gene
Official gene ID
6794(Refseq)
6794 (KEGG)
Transcript ID
NM_000455
Functional classification
Tumor growth and progression
Signaling pathway
PI3K/Akt/mTOR
Chromosomal location
19p13.3 (chr19:1206913..1226646)
Protein length
433

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr19:1206988 ATCCACCGCATCGAC A 1 / 10 p.I29fs c.84_97delCATCGACTCCACCG   Tier2 1 / 51
chr19:1207092 C G 1 / 10 p.Y60* c.180C>G COSV58821906 Tier2 1 / 51
chr19:1207162 A T 1 / 10 p.K84* c.250A>T COSV58820372 Tier2 1 / 51
chr19:1218422 TC T 2 / 10 p.Q100fs c.298delC COSV58830813 Tier2 1 / 51
chr19:1220375 C G 4 / 10 p.Y156* c.468C>G   Tier2 1 / 51
chr19:1220382 C T 4 / 10 p.Q159* c.475C>T COSV58820732 Tier2 1 / 51
chr19:1220408 GC G 4 / 10 p.H168fs c.502delC   Tier2 1 / 51
chr19:1220433 G A 4 / 10 p.D176N c.526G>A COSV58825680 Tier2 1 / 51
chr19:1220487 G T 4 / 10 p.D194Y c.580G>T COSV58820621 Tier1 1 / 51
chr19:1220612 C A 5 / 10 p.C210* c.630C>A COSV58824243 Tier2 1 / 51
chr19:1221243 G T 6 / 10 p.E256* c.766G>T COSV58820855 Tier2 1 / 51
chr19:1221956 G T 7 / 10 p.E291* c.871G>T COSV58820471 Tier2 1 / 51
chr19:1223059 G A 8 / 10 p.W332* c.996G>A COSV58821923 Tier2 1 / 51
chr19:1223132 G T 8 / 10 p.E357* c.1069G>T COSV100480973 Tier2 1 / 51