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TCF7L2

Basic information

Official gene symbol
transcription factor 7 like 2
Conventional gene symbol
TCF-4, TCF4
Classification
Oncogene / Tumor suppressor gene
Official gene ID
6934(Refseq)
6934 (KEGG)
Transcript ID
NM_001146274
Functional classification
Differentiation
Signaling pathway
WNT
Chromosomal location
10q25.2-q25.3 (chr10:114710516..114925731)
Protein length
602

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr10:114710625 CAG C 1 / 14 p.R39fs c.115_116delAG   Tier2 2 / 130
chr10:114710652 C A 1 / 14 p.S46* c.137C>A COSV60503242 Tier2 2 / 130
chr10:114710658 TA T 1 / 14 p.V49fs c.144delA   Tier2 1 / 130
chr10:114710666 G T 1 / 14 p.E51* c.151G>T COSV60508340 Tier2 1 / 130
chr10:114724353 C A 4 / 14 p.Y140* c.420C>A   Tier2 1 / 130
chr10:114799801 G A 5 / 14 p.W156* c.468G>A COSV100588727 Tier2 1 / 130
chr10:114900964 C T 6 / 14 p.Q192* c.574C>T COSV53345394 Tier2 1 / 130
chr10:114901049 T TA 6 / 14 p.P221fs c.660dupA COSV53336308 Tier2 1 / 130
chr10:114901050 A ACCAG 6 / 14 p.D223fs c.663_666dupAGCC   Tier2 1 / 130
chr10:114901050 AC A 6 / 14 p.P221fs c.662delC   Tier2 1 / 130
chr10:114903708 GA G 7 / 14 p.D238fs c.713delA   Tier2 1 / 130
chr10:114903752 A AATCCCCC 7 / 14 p.L257fs c.761_767dupCCCATCC   Tier2 1 / 130
chr10:114905777 C T 8 / 14 p.Q266* c.796C>T   Tier2 1 / 130
chr10:114910854 C T 9 / 14 p.Q325* c.973C>T COSV53351359 Tier2 1 / 130
chr10:114910857 A AGT 9 / 14 p.D327fs c.978_979dupTG   Tier2 1 / 130
chr10:114912149 C T 11 / 14 p.R407* c.1219C>T COSV53338146 Tier2 3 / 130
chr10:114912161 A AT 11 / 14 p.M411fs c.1232dupT COSV53341621 Tier2 1 / 130
chr10:114912172 C G 11 / 14 p.Y414* c.1242C>G   Tier2 1 / 130
chr10:114912196 CTATG C 11 / 14 p.Y423fs c.1269_1269+3delTGTA   Tier2 1 / 130
chr10:114912196 CTA C 11 / 14 p.Y423fs c.1268_1269delAT COSV53335869 Tier2 1 / 130
chr10:114920435 G A 13 / 14 p.W459* c.1376G>A   Tier2 1 / 130
chr10:114920436 G A 13 / 14 p.W459* c.1377G>A   Tier2 1 / 130