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TET2

Basic information

Official gene symbol
tet methylcytosine dioxygenase 2
Conventional gene symbol
KIAA1546
Classification
Tumor suppressor gene
Official gene ID
54790(Refseq)
54790 (KEGG)
Transcript ID
NM_001127208
Functional classification
Epigenetic regulation
Signaling pathway
Epigenetic modification
Chromosomal location
4q24 (chr4:106155100..106197676)
Protein length
2,002

Chromosome ideogram

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr4:106155565 C T 3 / 11 p.Q156* c.466C>T COSV54425813 Tier2 1 / 102
chr4:106155637 C T 3 / 11 p.Q180* c.538C>T COSV54438038 Tier2 1 / 102
chr4:106155755 AAC A 3 / 11 p.H222fs c.664_665delCA   Tier2 1 / 102
chr4:106155769 G T 3 / 11 p.E224* c.670G>T   Tier2 1 / 102
chr4:106156180 C T 3 / 11 p.Q361* c.1081C>T   Tier2 1 / 102
chr4:106156299 ACCATCACAATT A 3 / 11 p.P401fs c.1201_1211delCCATCACAATT   Tier2 1 / 102
chr4:106156590 TG T 3 / 11 p.V498fs c.1492delG   Tier2 1 / 102
chr4:106157788 C T 3 / 11 p.Q897* c.2689C>T COSV99484202 Tier2 1 / 102
chr4:106162507 G T 4 / 11 p.E1141* c.3421G>T COSV104597607 Tier2 1 / 102
chr4:106162570 G T 4 / 11 p.E1162* c.3484G>T   Tier2 1 / 102
chr4:106164061 C T 5 / 11 p.Q1191* c.3571C>T COSV54397396 Tier2 1 / 102
chr4:106164069 T A 5 / 11 p.C1193* c.3579T>A   Tier2 1 / 102
chr4:106164778 C T 6 / 11 p.R1216* c.3646C>T COSV54398925 Tier2 1 / 102
chr4:106196561 C T 11 / 11 p.Q1632* c.4894C>T COSV54414068 Tier2 1 / 102
chr4:106196771 C T 11 / 11 p.Q1702* c.5104C>T COSV54412815 Tier2 1 / 102
chr4:106197633 A AT 11 / 11 p.A1990fs c.5967dupT   Tier2 1 / 102