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TP53

Basic information

Official gene symbol
tumor protein p53
Conventional gene symbol
BCC7, BMFS5, LFS1, P53, TRP53
Classification
Oncogene / Tumor suppressor gene
Official gene ID
7157(Refseq)
7157 (KEGG)
Transcript ID
NM_000546
Functional classification
Genome maintenance
Signaling pathway
TP53
Chromosomal location
17p13.1 (chr17:7572927..7579912, complement)
Protein length
393

Chromosome ideogram

Pathway map

Frequency of somatic alterationsTumor type

Base substitutions, insertions, and deletions

Copy number alterations

Distribution of tumor mutation burdenTMB

List of driver somatic mutations

Genomic Coordinates (GRCh37/hg19) Reference Variant Exon Amino Acid change Coding DNA change COSMIC (v92) Classification No. of Samples
chr17:7579707 TTG T 3 / 11 p.N29fs c.87_88delCA COSV53495060 Tier2 1 / 2111
chr17:7578555 C T 4 / 11   c.376-1G>A COSV52688618 Tier2 5 / 2111
chr17:7578555 C G 4 / 11   c.376-1G>C COSV52996344 Tier2 1 / 2111
chr17:7578555 C A 4 / 11   c.376-1G>T COSV52749979 Tier2 1 / 2111
chr17:7578556 T C 4 / 11   c.376-2A>G COSV52689235 Tier2 6 / 2111
chr17:7578556 T A 4 / 11   c.376-2A>T COSV52691326 Tier2 1 / 2111
chr17:7579309 GACCGTGCAAGTC G 4 / 11 p.C124fs c.366_375+2delGACTTGCACGGT   Tier2 1 / 2111
chr17:7579310 A G 4 / 11   c.375+2T>C COSV52664353 Tier2 3 / 2111
chr17:7579310 A T 4 / 11   c.375+2T>A COSV52663814 Tier2 1 / 2111
chr17:7579311 C T 4 / 11   c.375+1G>A COSV52663569 Tier2 5 / 2111
chr17:7579311 C G 4 / 11   c.375+1G>C COSV52668477 Tier2 2 / 2111
chr17:7579312 C T 4 / 11 p.T125T c.375G>A COSV52718605 Tier2 8 / 2111
chr17:7579312 C A 4 / 11 p.T125T c.375G>T COSV52665709 Tier2 6 / 2111
chr17:7579312 C G 4 / 11 p.T125T c.375G>C COSV53120615 Tier2 2 / 2111
chr17:7579313 G A 4 / 11 p.T125M c.374C>T COSV52673504 Tier2 6 / 2111
chr17:7579313 G C 4 / 11 p.T125R c.374C>G COSV52688693 Tier2 2 / 2111
chr17:7579313 G T 4 / 11 p.T125K c.374C>A COSV52667346 Tier2 1 / 2111
chr17:7579315 G T 4 / 11 p.C124* c.372C>A COSV52944837 Tier2 3 / 2111
chr17:7579320 TCA T 4 / 11 p.V122fs c.365_366delTG COSV52686027 Tier2 4 / 2111
chr17:7579322 AC A 4 / 11 p.V122fs c.364delG   Tier2 1 / 2111
chr17:7579329 T C 4 / 11 p.K120E c.358A>G COSV52692352 Tier1 1 / 2111
chr17:7579331 GCTGTC G 4 / 11 p.T118fs c.351_355delGACAG   Tier2 1 / 2111
chr17:7579334 GT G 4 / 11 p.T118fs c.352delA COSV53087696 Tier2 1 / 2111
chr17:7579339 AGAATGCAAGAAGCCCAGAC A 4 / 11 p.R110fs c.329_347delGTCTGGGCTTCTTGCATTC   Tier2 1 / 2111
chr17:7579344 G GC 4 / 11 p.H115fs c.342dupG COSV52923620 Tier2 1 / 2111
chr17:7579353 CCA C 4 / 11 p.L111fs c.332_333delTG COSV52832180 Tier2 1 / 2111
chr17:7579355 A T 4 / 11 p.L111Q c.332T>A COSV52699193 Tier2 5 / 2111
chr17:7579355 A C 4 / 11 p.L111R c.332T>G COSV52676090 Tier2 2 / 2111
chr17:7579357 ACGGAAAC A 4 / 11 p.G108fs c.323_329delGTTTCCG COSV53245023 Tier2 1 / 2111
chr17:7579358 C A 4 / 11 p.R110L c.329G>T COSV52662399 Tier2 11 / 2111
chr17:7579358 CG C 4 / 11 p.R110fs c.328delC COSV52762007 Tier2 2 / 2111
chr17:7579371 T TG 4 / 11 p.S106fs c.315dupC   Tier2 1 / 2111
chr17:7579377 G A 4 / 11 p.Q104* c.310C>T COSV52694629 Tier2 3 / 2111
chr17:7579377 GGTAGGTTT G 4 / 11 p.K101fs c.302_309delAAACCTAC   Tier2 1 / 2111
chr17:7579378 G C 4 / 11 p.Y103* c.309C>G COSV52776039 Tier2 1 / 2111
chr17:7579378 G T 4 / 11 p.Y103* c.309C>A COSV52663474 Tier2 1 / 2111
chr17:7579389 G A 4 / 11 p.Q100* c.298C>T COSV52702138 Tier2 2 / 2111
chr17:7579396 GAC G 4 / 11 p.V97fs c.289_290delGT   Tier2 1 / 2111
chr17:7579400 GAA G 4 / 11 p.S96fs c.285_286delTT COSV104581948 Tier2 1 / 2111
chr17:7579406 G T 4 / 11 p.S94* c.281C>A COSV52677652 Tier2 1 / 2111
chr17:7579407 ACAGGGGC A 4 / 11 p.W91fs c.273_279delGCCCCTG   Tier2 1 / 2111
chr17:7579407 ACAGGGGCCAGGAGGGGGCTGGTG A 4 / 11 p.A86fs c.257_279delCACCAGCCCCCTCCTGGCCCCTG COSV52813733 Tier2 1 / 2111
chr17:7579408 CAG C 4 / 11 p.L93fs c.277_278delCT COSV52989547 Tier2 1 / 2111
chr17:7579411 G GGGCCAGGA 4 / 11 p.L93fs c.268_275dupTCCTGGCC   Tier2 1 / 2111
chr17:7579414 C T 4 / 11 p.W91* c.273G>A COSV52673580 Tier2 3 / 2111
chr17:7579415 C T 4 / 11 p.W91* c.272G>A COSV52734595 Tier2 1 / 2111
chr17:7579431 C CA 4 / 11 p.A86fs c.255dupT COSV104581950 Tier2 1 / 2111
chr17:7579439 GC G 4 / 11 p.A83fs c.247delG COSV52972073 Tier2 1 / 2111
chr17:7579445 G GT 4 / 11 p.T81fs c.241dupA COSV52997703 Tier2 1 / 2111
chr17:7579452 CT C 4 / 11 p.A79fs c.234delA   Tier2 1 / 2111
chr17:7579465 G GT 4 / 11 p.A76fs c.221_222insA   Tier2 1 / 2111
chr17:7579480 AG A 4 / 11 p.A69fs c.206delC COSV53876381 Tier2 1 / 2111
chr17:7579494 T A 4 / 11 p.R65* c.193A>T COSV52689560 Tier2 1 / 2111
chr17:7579503 C A 4 / 11 p.E62* c.184G>T COSV52811974 Tier2 1 / 2111
chr17:7579521 C A 4 / 11 p.E56* c.166G>T COSV52883452 Tier2 1 / 2111
chr17:7579528 C T 4 / 11 p.W53* c.159G>A COSV52751414 Tier2 2 / 2111
chr17:7579529 C T 4 / 11 p.W53* c.158G>A COSV52774899 Tier2 1 / 2111
chr17:7579536 C A 4 / 11 p.E51* c.151G>T COSV52694020 Tier2 2 / 2111
chr17:7579538 AT A 4 / 11 p.I50fs c.148delA   Tier2 1 / 2111
chr17:7579544 TCC T 4 / 11 p.D48fs c.141_142delGG   Tier2 1 / 2111
chr17:7579544 TC T 4 / 11 p.D48fs c.142delG COSV53225368 Tier2 1 / 2111
chr17:7579546 CGGGGACAGCATCAAATCATCCATTGCTTG C 4 / 11 p.Q38fs c.112_140delCAAGCAATGGATGATTTGATGCTGTCCCC   Tier2 1 / 2111
chr17:7579549 GGACAGCAT G 4 / 11 p.M44fs c.130_137delATGCTGTC   Tier2 1 / 2111
chr17:7579552 CA C 4 / 11 p.L45fs c.134delT   Tier2 1 / 2111
chr17:7579555 C CATCAA 4 / 11 p.M44fs c.127_131dupTTGAT   Tier2 2 / 2111
chr17:7579559 A T 4 / 11 p.L43* c.128T>A COSV52992944 Tier2 2 / 2111
chr17:7579563 C CTT 4 / 11 p.D42fs c.123_124insAA   Tier2 1 / 2111
chr17:7579563 CAT C 4 / 11 p.D41fs c.122_123delAT   Tier2 1 / 2111
chr17:7579575 G A 4 / 11 p.Q38* c.112C>T COSV52689258 Tier2 1 / 2111
chr17:7579582 CAA C 4 / 11 p.L35fs c.103_104delTT   Tier2 1 / 2111
chr17:7579583 A T 4 / 11 p.L35* c.104T>A COSV52728232 Tier2 1 / 2111
chr17:7579588 G GA 4 / 11 p.P36fs c.98_99insT COSV52779808 Tier2 1 / 2111
chr17:7578290 C T 5 / 11   c.560-1G>A COSV52662318 Tier2 2 / 2111
chr17:7578290 C A 5 / 11   c.560-1G>T COSV52676510 Tier2 3 / 2111
chr17:7578290 C G 5 / 11   c.560-1G>C COSV52690533 Tier2 1 / 2111
chr17:7578291 T G 5 / 11   c.560-2A>C COSV52685228 Tier2 3 / 2111
chr17:7578363 CTGCTCACCATCGCTA C 5 / 11 p.D184fs c.552_559+7delTAGCGATGGTGAGCA   Tier2 1 / 2111
chr17:7578369 A C 5 / 11   c.559+2T>G COSV52900265 Tier2 3 / 2111
chr17:7578369 A G 5 / 11   c.559+2T>C COSV53486980 Tier2 2 / 2111
chr17:7578369 A T 5 / 11   c.559+2T>A COSV52709511 Tier2 1 / 2111
chr17:7578370 C T 5 / 11   c.559+1G>A COSV52670017 Tier2 5 / 2111
chr17:7578370 C A 5 / 11   c.559+1G>T COSV52695669 Tier2 1 / 2111
chr17:7578375 GCTAT G 5 / 11 p.D184fs c.551_554delATAG COSV53347129 Tier2 1 / 2111
chr17:7578377 TA T 5 / 11 p.D184fs c.552delT   Tier2 1 / 2111
chr17:7578378 AT A 5 / 11 p.D184fs c.551delA COSV53082292 Tier2 1 / 2111
chr17:7578382 G C 5 / 11 p.S183* c.548C>G COSV52662121 Tier2 1 / 2111
chr17:7578382 G T 5 / 11 p.S183* c.548C>A COSV52858115 Tier2 1 / 2111
chr17:7578388 C G 5 / 11 p.R181P c.542G>C COSV52676870 Tier2 2 / 2111
chr17:7578388 C T 5 / 11 p.R181H c.542G>A COSV52675795 Tier2 2 / 2111
chr17:7578389 G A 5 / 11 p.R181C c.541C>T COSV52689134 Tier2 1 / 2111
chr17:7578392 C A 5 / 11 p.E180* c.538G>T COSV52694461 Tier2 3 / 2111
chr17:7578392 C T 5 / 11 p.E180K c.538G>A COSV52816009 Tier2 1 / 2111
chr17:7578393 A T 5 / 11 p.H179Q c.537T>A COSV52669519 Tier2 2 / 2111
chr17:7578394 T C 5 / 11 p.H179R c.536A>G COSV52661712 Tier2 15 / 2111
chr17:7578394 T A 5 / 11 p.H179L c.536A>T COSV52690692 Tier1 1 / 2111
chr17:7578395 G A 5 / 11 p.H179Y c.535C>T COSV52662617 Tier2 6 / 2111
chr17:7578395 G C 5 / 11 p.H179D c.535C>G COSV52668276 Tier2 2 / 2111
chr17:7578398 G C 5 / 11 p.H178D c.532C>G COSV52693338 Tier2 1 / 2111
chr17:7578402 G T 5 / 11 p.C176* c.528C>A COSV52701599 Tier2 1 / 2111
chr17:7578402 G C 5 / 11 p.C176W c.528C>G COSV52735850 Tier2 1 / 2111
chr17:7578403 C A 5 / 11 p.C176F c.527G>T COSV52661329 Tier2 15 / 2111
chr17:7578403 C T 5 / 11 p.C176Y c.527G>A COSV52660760 Tier2 9 / 2111
chr17:7578404 A G 5 / 11 p.C176R c.526T>C COSV52682539 Tier2 1 / 2111
chr17:7578406 C T 5 / 11 p.R175H c.524G>A COSV52661038 Tier1 135 / 2111
chr17:7578407 G C 5 / 11 p.R175G c.523C>G COSV52717943 Tier2 1 / 2111
chr17:7578411 CA C 5 / 11 p.V173fs c.518delT   Tier2 1 / 2111
chr17:7578412 A G 5 / 11 p.V173A c.518T>C COSV52679619 Tier2 2 / 2111
chr17:7578413 C T 5 / 11 p.V173M c.517G>A COSV52677795 Tier2 5 / 2111
chr17:7578413 C A 5 / 11 p.V173L c.517G>T COSV52676535 Tier2 4 / 2111
chr17:7578413 C G 5 / 11 p.V173L c.517G>C COSV52695723 Tier2 1 / 2111
chr17:7578418 TC T 5 / 11 p.E171fs c.511delG COSV52796495 Tier2 1 / 2111
chr17:7578419 C A 5 / 11 p.E171* c.511G>T COSV52671445 Tier2 4 / 2111
chr17:7578427 T C 5 / 11 p.H168R c.503A>G COSV52698349 Tier2 2 / 2111
chr17:7578428 G GCT 5 / 11 p.H168fs c.500_501dupAG   Tier2 1 / 2111
chr17:7578431 G A 5 / 11 p.Q167* c.499C>T COSV52735517 Tier2 5 / 2111
chr17:7578432 T TGACTG 5 / 11 p.Q167fs c.493_497dupCAGTC   Tier2 1 / 2111
chr17:7578433 G T 5 / 11 p.S166* c.497C>A COSV52661795 Tier2 1 / 2111
chr17:7578437 G A 5 / 11 p.Q165* c.493C>T COSV52677910 Tier2 10 / 2111
chr17:7578440 TG T 5 / 11 p.Y163fs c.489delC COSV52741368 Tier2 1 / 2111
chr17:7578441 G C 5 / 11 p.Y163* c.489C>G COSV53211332 Tier2 1 / 2111
chr17:7578442 T C 5 / 11 p.Y163C c.488A>G COSV52663142 Tier2 9 / 2111
chr17:7578443 A G 5 / 11 p.Y163H c.487T>C COSV52661160 Tier2 3 / 2111
chr17:7578443 A C 5 / 11 p.Y163D c.487T>G COSV52853225 Tier2 1 / 2111
chr17:7578448 GCCAT G 5 / 11 p.M160fs c.478_481delATGG   Tier2 1 / 2111
chr17:7578449 C T 5 / 11 p.A161T c.481G>A COSV52660939 Tier2 5 / 2111
chr17:7578452 TG T 5 / 11 p.M160fs c.477delC COSV52693942 Tier2 1 / 2111
chr17:7578453 G GGC 5 / 11 p.M160fs c.475_476dupGC   Tier2 1 / 2111
chr17:7578453 G GC 5 / 11 p.M160fs c.476_477insG   Tier2 1 / 2111
chr17:7578457 C T 5 / 11 p.R158H c.473G>A COSV52680378 Tier2 11 / 2111
chr17:7578457 C A 5 / 11 p.R158L c.473G>T COSV52676395 Tier2 11 / 2111
chr17:7578457 CG C 5 / 11 p.R158fs c.472delC COSV52921244 Tier2 1 / 2111
chr17:7578458 G A 5 / 11 p.R158C c.472C>T COSV52677865 Tier2 1 / 2111
chr17:7578460 A T 5 / 11 p.V157D c.470T>A COSV52699845 Tier1 4 / 2111
chr17:7578460 A AC 5 / 11 p.V157fs c.469dupG   Tier2 1 / 2111
chr17:7578461 C A 5 / 11 p.V157F c.469G>T COSV52667015 Tier1 11 / 2111
chr17:7578463 CGGGTGCCGGGCGG C 5 / 11 p.P152fs c.454_466delCCGCCCGGCACCC COSV52793232 Tier2 1 / 2111
chr17:7578469 CCGGGCGGGGGT C 5 / 11 p.P151fs c.450_460delACCCCCGCCCG   Tier2 1 / 2111
chr17:7578469 CCGGGCGGGGGTGT C 5 / 11 p.T150fs c.448_460delACACCCCCGCCCG COSV52702198 Tier2 1 / 2111
chr17:7578470 CG C 5 / 11 p.G154fs c.459delC COSV53030246|COSV53217712 Tier2 1 / 2111
chr17:7578475 G A 5 / 11 p.P152L c.455C>T COSV52666949 Tier2 11 / 2111
chr17:7578479 G A 5 / 11 p.P151S c.451C>T COSV52661698 Tier1 7 / 2111
chr17:7578479 G T 5 / 11 p.P151T c.451C>A COSV52676321 Tier1 1 / 2111
chr17:7578479 G C 5 / 11 p.P151A c.451C>G COSV52701855 Tier2 2 / 2111
chr17:7578492 C T 5 / 11 p.W146* c.438G>A COSV52661500 Tier2 7 / 2111
chr17:7578493 C T 5 / 11 p.W146* c.437G>A COSV52661900 Tier2 3 / 2111
chr17:7578499 T G 5 / 11 p.Q144P c.431A>C COSV52661000 Tier2 2 / 2111
chr17:7578500 G A 5 / 11 p.Q144* c.430C>T COSV52662339 Tier2 4 / 2111
chr17:7578502 A G 5 / 11 p.V143A c.428T>C COSV52760297 Tier2 1 / 2111
chr17:7578502 AC A 5 / 11 p.V143fs c.427delG COSV53135444 Tier2 1 / 2111
chr17:7578506 G GT 5 / 11 p.P142fs c.423_424insA   Tier2 1 / 2111
chr17:7578507 G C 5 / 11 p.C141W c.423C>G COSV52706449 Tier2 2 / 2111
chr17:7578508 C T 5 / 11 p.C141Y c.422G>A COSV52664953 Tier2 5 / 2111
chr17:7578509 A G 5 / 11 p.C141R c.421T>C COSV52675559 Tier2 2 / 2111
chr17:7578515 TG T 5 / 11 p.K139fs c.414delC COSV52708439 Tier2 1 / 2111
chr17:7578515 T A 5 / 11 p.K139* c.415A>T COSV52698907 Tier2 1 / 2111
chr17:7578517 GC G 5 / 11 p.A138fs c.412delG COSV52688445 Tier2 1 / 2111
chr17:7578524 G A 5 / 11 p.Q136* c.406C>T COSV52676850 Tier2 6 / 2111
chr17:7578525 G T 5 / 11 p.C135* c.405C>A COSV52665429 Tier2 1 / 2111
chr17:7578525 G C 5 / 11 p.C135W c.405C>G COSV52669330 Tier2 1 / 2111
chr17:7578526 C A 5 / 11 p.C135F c.404G>T COSV52680475 Tier2 9 / 2111
chr17:7578526 C T 5 / 11 p.C135Y c.404G>A COSV52675774 Tier2 8 / 2111
chr17:7578527 A C 5 / 11 p.C135G c.403T>G COSV52827707 Tier2 1 / 2111
chr17:7578530 ACATCTTGTTGAGGG A 5 / 11 p.A129fs c.386_399delCCCTCAACAAGATG   Tier2 1 / 2111
chr17:7578530 AC A 5 / 11 p.M133fs c.399delG   Tier2 1 / 2111
chr17:7578531 CATCTTGT C 5 / 11 p.N131fs c.392_398delACAAGAT   Tier2 1 / 2111
chr17:7578531 CATCTTGTTGA C 5 / 11 p.L130fs c.389_398delTCAACAAGAT   Tier2 1 / 2111
chr17:7578532 ATCTTGTTGAGGGCAGGGGAGTACTGTAG A 5 / 11 p.Y126fs c.376-6_397delCTACAGTACTCCCCTGCCCTCAACAAGA   Tier2 1 / 2111
chr17:7578534 C G 5 / 11 p.K132N c.396G>C COSV52688381 Tier2 2 / 2111
chr17:7578534 C A 5 / 11 p.K132N c.396G>T COSV52705927 Tier2 2 / 2111
chr17:7578534 C CT 5 / 11 p.M133fs c.395dupA COSV53104865 Tier2 1 / 2111
chr17:7578535 T A 5 / 11 p.K132M c.395A>T COSV52701687 Tier2 1 / 2111
chr17:7578535 T C 5 / 11 p.K132R c.395A>G COSV52666637 Tier2 7 / 2111
chr17:7578536 T A 5 / 11 p.K132* c.394A>T COSV52979406 Tier2 1 / 2111
chr17:7578536 T C 5 / 11 p.K132E c.394A>G COSV52689323 Tier2 1 / 2111
chr17:7578538 TTGAGGGCAGGG T 5 / 11 p.P128fs c.381_391delCCCTGCCCTCA   Tier2 1 / 2111
chr17:7578552 G T 5 / 11 p.Y126* c.378C>A COSV52757878 Tier2 1 / 2111
chr17:7578553 T TA 5 / 11 p.Y126fs c.376dupT   Tier2 1 / 2111
chr17:7577609 C A 6 / 11   c.673-1G>T COSV52705331 Tier2 3 / 2111
chr17:7577609 C T 6 / 11   c.673-1G>A COSV52662773 Tier2 3 / 2111
chr17:7577610 T C 6 / 11   c.673-2A>G COSV52682653 Tier2 5 / 2111
chr17:7577610 T A 6 / 11   c.673-2A>T COSV52669186 Tier2 1 / 2111
chr17:7577610 T G 6 / 11   c.673-2A>C COSV52687702 Tier2 1 / 2111
chr17:7578175 A T 6 / 11   c.672+2T>A COSV52797769 Tier2 1 / 2111
chr17:7578175 A G 6 / 11   c.672+2T>C COSV52677962 Tier2 1 / 2111