機能分類・シグナル伝達経路

機能分類 シグナル伝達経路 遺伝子数 遺伝子シンボル名
細胞周期 Cell cycle 14 BTG2, CCND1, CCND2, CCND3, CCNE1, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, RB1, SKP2
Cell division 5 AURKA, AURKB, KNSTRN, RAD21, STAG2
細胞死 Apoptosis 9 BAX, BCL2, BCL2L1, BCL2L11, BCL2L2, CASP8, DAXX, FAS, MCL1
腫瘍形成・増殖 GPCR 9 CXCR4, GNA11, GNA13, GNAQ, GNAS, GRM3, P2RY8, S1PR3, TSHR
Hippo 1 NF2
JAK/STAT 10 CALR, CRLF2, CSF3R, JAK1, JAK2, JAK3, MPL, PIM1, SOCS1, STAT3
MAPK 26 ARAF, BRAF, CIC, HRAS, KRAS, LZTR1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K4, MAPK1, MKNK1, NF1, NRAS, PTPN11, RAC1, RAC2, RAF1, RHOA, RIT1, RRAS2, SHOC2, SOS1, SRC
MYC 5 MAX, MXI1, MYC, MYCL, MYCN
NFKB 6 BCL10, CARD11, MYD88, NFKBIA, REL, TNFAIP3
Nuclear receptor 4 AR, ESR1, PPARG, RARA
PI3K/Akt/mTOR 28 AKT1, AKT2, AKT3, CRKL, EPAS1, FLCN, INPP4B, MTOR, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PPP2R1A, PPP2R2A, PRKAR1A, PTEN, RHEB, RICTOR, RPTOR, SGK1, STK11, TMEM127, TSC1, TSC2, VHL
RTK 52 ABL1, ABL2, ALK, AXL, CBL, DDR1, DDR2, EGFR, EPHA3, EPHB1, EPHB4, ERBB2, ERBB3, ERBB4, ERRFI1, FGF10, FGF12, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT3, HGF, IGF1R, IGF2, IRS2, KDR, KIT, MET, MST1R, NRG1, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTPRK, PTPRO, PTPRT, RET, ROS1, TEK, TNK2, TYRO3, VEGFA
TGF-B 7 ACVR1B, BMPR1A, ENG, SMAD2, SMAD4, TGFBR1, TGFBR2
分化 Hedgehog 4 PRKCI, PTCH1, SMO, SUFU
NOTCH 6 HDAC2, HEY1, MAML2, NOTCH1, NOTCH2, NOTCH3
WNT 14 AMER1, APC, AXIN1, CDH1, CTNNA1, CTNNB1, FAT1, GSK3B, LRP5, RNF43, RSPO2, RSPO3, SOX9, TCF7L2
ゲノム安定性の維持 Core DNA Damage Response 27 BARD1, BLM, BRCA1, BRCA2, BRIP1, ERCC2, ERCC4, FANCA, FANCC, FANCL, MLH1, MRE11, MSH2, MSH3, MSH6, NBN, PALB2, PARP1, PMS1, PMS2, POLE, RAD50, RAD51, RAD52, UBE2T, XPA, XRCC2
DNA damage control 14 FANCG, MUTYH, PARP2, PARP3, POLD1, POLH, RAD51B, RAD51C, RAD51D, RAD54L, RECQL4, SLX4, TERC, TERT
TP53 7 ATM, ATR, CHEK1, CHEK2, MDM2, MDM4, TP53
免疫 Immune 22 ALOX12B, B2M, BCL6, BTK, CD22, CD274, CD70, CD74, CD79A, CD79B, CSF1R, CTLA4, IKBKE, IL7R, IRF2, IRF4, LYN, PDCD1, PDCD1LG2, SH2D1A, SYK, TNFRSF14
代謝 Drug metabolism 19 ABCB1, ABCG2, ALDH2, CDA, COMT, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DPYD, MTHFR, NAT2, TPMT, UGT1A1
Metabolic pathway 22 ADH1B, CYP17A1, CYP3A43, EXT1, EXT2, FH, G6PD, GALNT12, HSD3B1, MTAP, MTRR, NT5C2, PDE11A, PDGFB, PDK1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SLC22A18, TIPARP
酸化ストレス応答 KEAP1/NRF2 3 CUL3, KEAP1, NFE2L2
タンパク質の恒常性の維持 Protein homeostasis 10 BAP1, CUL4A, CYLD, ENO1, FBXW7, MKRN1, PRKN, RBBP6, SPOP, TRAF7
エピジェネティック制御 Epigenetic modification 39 ARID1A, ARID1B, ARID2, ASXL1, ATRX, BCOR, BCORL1, CREBBP, CTCF, DNMT1, DNMT3A, DOT1L, EED, EP300, EZH2, H3-3A, HDAC1, IDH1, IDH2, KDM5A, KDM5C, KDM6A, KMT2A, KMT2C, KMT2D, MEN1, NCOA2, NCOA3, NCOR1, NPM1, PBRM1, PPP6C, SETBP1, SETD2, SMARCA4, SMARCB1, TET2, NSD2, NSD3
転写制御 RNA metabolism 12 BTG1, DICER1, DIS3, EIF3E, EWSR1, TENT5C, QKI, RBM10, SF3B1, TACC3, U2AF1, XPO1
Transcriptional regulation 51 ATF1, BRD4, CBFB, CDC73, CDK8, CDK12, CEBPA, CRTC3, DDIT3, ERG, ETV4, ETV5, ETV6, FOXL2, FUBP1, FUS, GATA3, GATA4, GATA6, HMGA2, HNF1A, HOXB13, ID3, IKZF1, JUN, KLF4, LMO1, MAF, MED12, MEF2B, MITF, MYB, NCOA4, NFIB, NKX2-1, PAX5, PHOX2B, PLAG1, PRDM1, RUNX1, SALL4, SOX2, SPEN, SS18, SSX1, TBX3, TMPRSS2, TP63, WT1, ZNF217, ZNF703
その他 --- 34 ACTN4, AIP, ARFRP1, BCR, CCDC6, CDH23, CHCHD7, COL1A1, DNAAF1, EML4, EMSY, EPCAM, EZR, GABRA6, GID4, KEL, KIAA1549, KIF1B, KIF5B, KLHL6, LTK, MC1R, MERTK, NCF2, NUTM1, RUNDC1, SAMD9, SDC4, SLC34A2, SNCAIP, SPINK1, STRN, TPM3, VTI1A